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Gates： He saved more lives than any scientist in the 20th century, but Fauci said that he was also unknown in the scientific community.

Originality brings science home.

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In 2016, Bill Gates once commented on a person: He may have saved more lives than any scientist in the 20th century. And Fauci said that this person is also unknown in the scientific community.

Saved so many people but didn’t become famous. This person is Maurice Hilleman.

Maurice Hilleman Image source: nfid.org

Hillemann developed more than 40 kinds of vaccines in his life, and now he invented 8 of the 14 kinds of conventional vaccines for children. He is also the first person in the world who successfully predicted and stopped the pandemic of infectious diseases.

It is estimated that the vaccine developed in Hillemann saves 8 million lives every year. It is no exaggeration to say that he is the guardian of your life and mine. Today, let’s take a look at this hero who does not strive for fame and success.

Hillerman was born on August 40, 1919, the eighth child in his family. Shortly after his birth, his mother and twin sister also passed away. Later, he was adopted to a childless uncle family. Uncle Bichler Mann’s biological father is more enlightened, so he has more opportunities to explore and expand his hobbies.

Childhood Hillemann Image Source: hillemanfilm.com

It is such a child who is interested in Darwin’s theory of evolution. Because of his poor family, he almost didn’t go to college. After graduating from high school, he got a job at J. C. Penney, and he planned to spend his life like this. Fortunately, his eldest brother mediated and helped him get a scholarship from Montana State University. In 1941, he graduated from the school with the first grade.

Then he went to the University of Chicago to study for a doctorate. During his PhD, he studied chlamydia, the pathogen of a common sexually transmitted disease.

In the 1940s, the medical community generally classified chlamydia as a virus. However, Hillemann discovered through research that Chlamydia trachomatis is a special kind of bacteria. Chlamydia trachomatis can only live in cells and is a parasitic bacterium.

Chlamydia trachomatis (brown) Image source: wikipedia

Since it is caused by bacteria, chlamydia can be treated with antibiotics. This is the first city captured by Hillemann for human health.

After obtaining his doctorate, he did not stay in academia, but entered a pharmaceutical company called E.R. Squibb & Sons and began to develop vaccines.

He quickly developed his first vaccine: Japanese encephalitis vaccine. Most encephalitis is caused by Japanese encephalitis virus. After being infected by Japanese encephalitis virus, the patient’s brain swells and the mortality rate is high. During World War II, the Japanese encephalitis vaccine developed by Hillemann was used to immunize the US military.

Japanese encephalitis virus is transmitted by mosquitoes.

In 1949, Hillemann became the chief scientist of respiratory diseases in The Walter Reed Army Institute of Research, when he began to study influenza virus.

During this period, he made several important discoveries about influenza virus. He pointed out to the world for the first time that the spike protein on the surface of influenza virus will change, avoiding the recognition of immune system. Everyone should have heard of spike protein. This year, the COVID-19 vaccine jointly developed by German pharmaceutical company BioNTech and Pfizer was immunized by training human immune system to recognize spike protein on the surface of Covid-19.

Later, biologists called this change of virus antigenic drift, and the major variation was called antigenic shift.

Antigenic transformation often leads to epidemic outbreaks, because few people in the world are immune to the new virus after the virus mutates.

In order to achieve antigenic transformation, the influenza virus that infects people needs two tool animals: birds and pigs. Pigs can be infected by both avian influenza virus and human influenza virus. Therefore, the two viruses can communicate in pigs to form a new and stronger influenza virus.

Hillemann’s discovery explains why the flu vaccine developed by the US military usually fails in the second year, and also helps him save millions of lives.

On April 17th, 1957, The New York Times reported the news of a large-scale influenza outbreak in Hongkong. Many Americans don’t think this is a disaster in a foreign country, and it has nothing to do with themselves. But Hillemann was keenly aware that the news was not simple.

During the Asian flu in July 1968, patients waiting for treatment in a clinic in Hong Kong. Image source: SCMP

The day after reading this report, he sent a telegram to an army medical general laboratory in Zama, Japan, and obtained the saliva of an infected American soldier.

After studying the patient’s saliva, Hillemann found that only a small group of old people who had experienced the "Russian influenza" pandemics in 1889 and 1890 had immunity, while younger people had no resistance to the new influenza virus.

Hillemann realized that the global influenza pandemic had arrived, and began to actively promote the development of influenza vaccine before the start of school in autumn.

In September 1957, an epidemic named the Asian flu entered the United States. However, at that time, the United States had produced and distributed 40 million doses of influenza vaccine, and the research and development time of the vaccine was only four months.

This is the attendance of a primary school in Tokyo when the Asian flu broke out at that time.

In the end, this virus (Type A2) called "Asian Influenza" caused about 70,000 deaths in the United States. But in 1957-1958, the virus caused about 2 million deaths worldwide.

Leonard Burney, then director of the US Department of Health, said that without this vaccine, millions of people in the United States would have died of the flu.

In this way, Hillemann became the first person in history to accurately predict the pandemic. Because of this incident, Hillemann was awarded the Distinguished Service Medal by the US military.

At the end of 1957, Hillemann began to work for Merck Pharmaceuticals and stayed there until he retired. At Merck, he developed vaccines against chickenpox, hepatitis A, hepatitis B, streptococcus pneumoniae, meningococcus, measles, mumps and rubella.

Mumps often leads to deafness. Image source: wikipedia

Hillemann was also the first person to integrate antiviral vaccines. With the triple vaccine against measles, mumps and rubella, children can gain immunity to measles, mumps and rubella only once.

Mumps vaccine has reduced the number of patients in the United States from 200,000 to 200 every year. The World Health Organization estimates that measles vaccine alone prevented 20.3 million deaths worldwide from 2000 to 2015.

There is another interesting story when it comes to the measles-mumps triple vaccine.

In fact, the virus used to make mumps vaccine was extracted from his adopted daughter Jeryl Lynn. Until now, the virus strain from his daughter is still being used to make mumps vaccine, and this virus strain is also named Jeryl Lynn strain.

Hillemann’s last invention-hepatitis B vaccine also made him the first person to fight cancer-liver cancer with a vaccine.

Hepatitis B virus is a major pathogen of liver cancer, the third largest cancer in the world. According to Baruch Blumberg, the Nobel Prize winner in 1976, there are about 375 million people in the world who are carriers of hepatitis B virus, and they are all at risk of liver cancer.

In order to develop hepatitis B vaccine, Hillemann did a very dangerous thing-purified hepatitis B surface antigen (HBsAg) from the blood of patients with hepatitis B and made hepatitis B vaccine.

Schematic diagram of hepatitis B surface antigen (purple)

There are two reasons why this matter is dangerous: First, in the process of research, hepatitis B virus may infect researchers.

Secondly, who wants to try a vaccine made of patient plasma at the cost of his life? After all, the protein of hepatitis B surface antigen is what hepatitis B virus does in human body to avoid the attack of immune system. Many people without medical background are afraid that they may be infected with hepatitis B after being injected with this protein.

In order to prove the effectiveness and safety of the vaccine, Hillemann personally went into battle and injected hepatitis B vaccine under the watchful eye of everyone.

Hillemann was vaccinated with the first generation of hepatitis B vaccine. Image source: vaccine makers project

However, because a new deadly disease, AIDS, appeared in the 1980s, many people were afraid that the hepatitis B vaccine purified from plasma might also carry the pathogen of AIDS, so the first generation of hepatitis B vaccine was in trouble.

However, Hillemann’s team soon found a way to make hepatitis B vaccine without human plasma. In 1986, they used gene technology to successfully make yeast produce HBsAg.

This vaccine is now used in 150 countries around the world. By 2003, the number of young hepatitis B patients in the United States had dropped by 95% compared with before the emergence of vaccines. Hepatitis B vaccine may be the medical product that saved the most people in the 20th century.

Hillemann believes that hepatitis B vaccine is the most important job in his life. Thomas Studds, a pioneer of liver transplantation, praised hepatitis B vaccine as "one of the greatest contributions to medicine in the 20th century. Hillemann has removed the biggest obstacle in the field of organ transplantation. "

After retirement, Hillemann became a consultant of the World Health Organization. In 1988, President Reagan awarded him the National Medal of Science award, the highest honor in American science.

Image source: the Hilleman Family

Although many people’s lives depend on him, few people outside the circle know his name and he didn’t win the Nobel Prize.

Robert Gallo, the co-discoverer of HIV virus, the pathogen of AIDS, once said: "If you want to name a person who has made great contributions to human health, but has not received due recognition, this person is Hillemann."

Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases, even said: "Even in the scientific community, few people know how much Morris has contributed. I recently asked my postdoctoral fellow if he knew who developed measles, mumps, rubella, hepatitis B and chickenpox vaccines. They said they didn’t know. "

Hillemann didn’t go out of the circle because of his low profile. Hillemann didn’t sign a paper to prove the effectiveness of hepatitis B vaccine, nor did he name any vaccine with his own name.

Hillemann seems to be the embodiment of human immune system. A healthy human body can’t benefit from the immune system, but TA has been silently protecting you in an invisible place.

Hillemann saved the most people in the 20th century, and some people’s hard disks saved the most people in the 21st century.

Untagged picture source network.

Reference materials are stored in graphite:

https://shimo.im/docs/cxWWVjVhRkTQ3YJc/

Original title: "Gates: He saved more lives than any scientist in the 20th century, but Fauci said he was unknown in the scientific community."

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COVID-19 XBB trivalent vaccine is fully launched! Further build a national immune barrier.

When the weather gets cold after entering winter, it may face the risk of mutual or co-epidemic of COVID-19, influenza and other respiratory infectious diseases, which will bring a new round of respiratory infectious disease infection peak, so it is urgent to prevent it in advance.

According to the report of China CDC, since 2023, the proportion of XBB mutants and their subfamilies in China has gradually increased, reaching 99% by the end of August. XBB series mutant is a kind of recombinant mutant in Omicron, and its spreading ability and immune escape ability are stronger than those of Omicron mutant which was popular in the early stage, so it is a global dominant strain at present.

Photo courtesy of the enterprise, issued by Yangguang. com

At the end of July, 2023, the State Council issued the Work Plan for Vaccination of Key Population in Covid-19 in the Near Future (hereinafter referred to as the Vaccination Plan) in response to the joint prevention and control mechanism of novel coronavirus infection. The Vaccination Plan clearly states that during the epidemic period of XBB mutant in Covid-19, especially in autumn and winter this year, it is recommended to vaccinate the vaccine containing XBB mutant antigen. The recombinant trivalent XBB Covid-19 trimer protein vaccine (Sf9 cells) developed by WEISKE Bio/Sichuan University Huaxi-VIKEXIN trivalent XBB vaccine has been officially launched in many places in China recently.

Photo courtesy of the enterprise, issued by Yangguang. com

The research shows that XBB mutant has strong immune escape ability and is prone to breakthrough infection, and the key population such as the elderly population is more harmful after being infected with XBB mutant. The "Vaccination Plan" points out that people aged 60 and above who have completed basic immunization or have been infected with Covid-19, or people aged 18-59 who have serious basic diseases, people with low immune function, and people with high risk of infection (including: civil affairs, health care, education, housing construction, transportation, public security, justice, state-owned assets, finance, market, cultural tourism, industrial letter, commerce, science and technology, people and society)

Photo courtesy of the enterprise, issued by Yangguang. com

In July this year, the State Council Joint Prevention and Control Mechanism promulgated the "Vaccination Plan", and the trivalent XBB vaccine of Wickham has been included in emergency use in a certain range, which can be used for vaccination of key populations in the near future. This vaccine is the world’s first broad-spectrum COVID-19 vaccine developed by West China of Sichuan University in conjunction with Wesker Biological Team to effectively prevent diseases caused by Covid-19 XBB.1.5 and other variants, and can effectively prevent diseases caused by current XBB and other variants Covid-19.

It is reported that at present, the 3-valent XBB vaccine of Wickham has been delivered, and will arrive at many CDC and inoculation units in the country one after another. Citizens who meet the inoculation conditions can consult the relevant CDC and inoculation units to make an appointment for vaccination.

Photo courtesy of the enterprise, issued by Yangguang. com

Accurate and powerful, better security.

Wickham trivalent XBB vaccine is a high-purity and high-quality trivalent mutant recombinant protein vaccine produced by Wesker Bio, which takes advantage of the rapid response of the international advanced insect cell technology platform to produce recombinant protein vaccine. Aiming at the spike protein receptor binding domain (S-RBD) and heptapeptide repeat domain (HR) of COVID-19 mutants such as XBB, the vaccine is prepared by accurately designing subunit vaccine antigen based on structure, self-assembling into stable protein particles with trimer structure, purifying and mixing, and adding oil-in-water emulsion adjuvant based on squalene. The innovative adjuvant greatly improved the titer of neutralizing antibody of the vaccine, and made the trimer protein vaccine induce a stronger T cell immune response in vivo.

The clinical trial data showed that the trivalent XBB vaccine of Vikexin could induce high-level neutralizing antibodies against the mutant strains such as XBB.1, XBB.1.5, XBB.1.16, XBB.1.9.1, EG.5, XBB.2.3, BA.5, etc., with good safety, which is of great significance to prevent the infection of mutant strains and reduce the severe disease rate and mortality rate.

It is reported that since May, 2023, the World Health Organization (WHO), the US Food and Drug Administration (FDA), the European Center for Disease Control and Prevention (ECDC) and the European Medicines Agency (EMA) have successively made suggestions on updating the composition of the vaccine in COVID-19 in 2023, and proposed that the new vaccine should induce neutralizing antibody reaction against the XBB mutant, the mainstream strain in COVID-19. WHO suggests that the elderly, young people with severe complications (such as diabetes and heart disease), people with low immune function and frontline health workers should be given priority to receive COVID-19 vaccine against XBB mutant.

In September, 2023, the Centers for Disease Control and Prevention (CDC) officially updated and recommended the XBB mutant COVID-19 vaccine in the United States, suggesting that people over 6 months in the United States should be vaccinated with the upgraded COVID-19 vaccine with XBB.1.5 as antigen in autumn and winter of 2023. According to US government data, as of mid-November, about 36 million adults have been vaccinated with the latest COVID-19 vaccine, which means that 13.9% of adults have been vaccinated with the upgraded XBB COVID-19 vaccine in the two months since the XBB vaccine was launched in the United States.

References:

1. the epidemic situation of infection in novel coronavirus in China. China center for disease control and prevention network.2023,9.https://www.chinacdc.cn/jkzt/CRB/ZL/szkb _ 11803/jszl _ 13141/202309/t20230906 _ 269361.html.

National COVID-19 Infection Epidemic Situation. Chinese Center for Disease Control and Prevention website. 2023, 9.https://www.chinacdc.cn/jkzt/crb/zl/szkb_11803/jszl_13141/202309/t20230906_269361.html

2.Callaway, E. COVID’s future: mini-waves rather than seasonal surges. Nature. 2023, 5. pp. 229？ 230

3. Bowe, Benjamin, et al. Acute and postacute sequelae associated with SARS-CoV-2 reinfection. Nature Medicine. 2022,11. pp. 2398-2405

4.WHO. SAGE updates COVID-19 vaccination guidance. SAGE updates COVID-19 vaccination guidance ( who.int )

5.Statement on the antigen composition of COVID-19 vaccines.WHO. 2023,5. https:// www.who.int/news/item/18-05-2023-statement-on-the-antigen-composition-of-covid-19-vaccines

6.EMA and ECDC statement on updating COVID-19 vaccines to target new SARS-CoV-2 virus variants.EMA.2023, 7. https:// www.ema.europa.eu/ en/news/ ema-ecdc- statement- updating-covid-19-vaccines-target-new-sars-cov-2-virus-variants

7. Product description of recombinant trivalent Covid-19 (XBB+BA.5+Delta mutant) trimer protein vaccine (Sf9 cell).

Package insert of Recombinant COVID-19 Trivalent (XBB + BA.5 + Delta) Protein Vaccine (Sf9 Cell)

(Note: This article belongs to the commercial information published by Yangguang. com, and the content of the article does not represent the views of this website, and it is for reference only)

Director Feng Delun, do you have any misunderstanding about stealing movies？ !

Special feature of 1905 film network　In the current film market, there are countless movies about theft, and the early movies in Hollywood and Hong Kong are quite outstanding. In particular, Hong Kong-made pirated films have also inspired and influenced some rising stars in the Mainland to a certain extent.

Nowadays, the series, series, series, series, etc. we see all incorporate many new elements in theft. Of course, domestic peers are also unique in this field.

On August 11th, a film about theft directed by Feng Delun was officially released. Compared with most of the theft movies mentioned above, Grand Theft Auto only stays at the level of completing a film. While insisting on his own personality, Feng Delun lost his control as a director, and his action scenes were abnormal, and his emotional scenes were unattractive, wrapping a mediocre idea with mediocre camera language.

First, deconstruct the story: the new tricks can’t be played, and the old routines fail.

The main characters in the story of Grand Theft Auto are two men and one woman. Andy Lau plays the wily team boss Zhang Dan, Yang Shining plays the hacker genius Chen Xiaobao, and Shu Qi plays the beautiful thief Ye Hong. This is basically a necessary setting for stealing films. One is responsible for decision-making, the other is responsible for seduction, and the other is responsible for technical support.

In fact, it is not difficult to see that the two men and one woman in Grand Theft Auto are very much like the film "Crossing the Seas" directed by John Woo in 1991. In "Around the World", three people with distinct personalities were entrusted with the task of stealing famous products but were framed. The story of "Grand Theft Auto" is exactly the same.

In terms of scene setting, the two are similar. The famous painting "Herring’s Maid" in "Around the World" and the jewelry "Soul Spring" in "Grand Theft Auto" are all hidden in the old castle. How to steal them has become the key point of the film.Feng Delun’s handling method is similar to stealing famous paintings in John Woo’s movies, but it does not have the tense atmosphere and romantic temperament created by John Woo.

In "Around the World", Chow Yun Fat and Leslie Cheung staged a classic passage of hiding from infrared rays with red wine in the process of stealing famous paintings. The two of them responded to the organs in a vigorous and agile way, and they also took a picture of the friendship of "a thousand cups of friends are few".

"Grand Theft Auto" also has passages about infrared organs, but the handling method of the film is that Yang Shining directly uses hacking technology to turn off infrared rays, which reduces the stimulation of passing through infrared rays. Comparatively speaking, the handling of this paragraph is very thin.

In "Around the World", Wu Yusen contributed to the classic bridge of making a big auction and stealing keys in the ballroom. Chow Yun Fat and Cherie Chung danced a classic wheelchair dance, which blended romanticism into the crime theme.

Look at "Grand Theft Auto" again, and there are also dancing scenes in the process of stealing famous paintings. Ye Hong, played by Shu Qi, dances with the collector, played by Sha Yi, in order to steal Sha Yi’s fingerprints. However, the props tied to Shu Qi’s body didn’t arouse Sha Yi’s suspicion at all, and he passed this test very easily, which was somewhat rash in handling.

In addition to Across the World, Feng Delun’s Grand Theft Auto has other movies. Pierre, a policeman played by Jean Reno, is an important figure in the film and an old friend of Andy Lau in the film. His life seems to be aimed at catching Zhang Dan to gain a sense of accomplishment.

The chase between Jean Reno and Andy Lau is like another work directed by John Woo and Spielberg’s. Li Xiuxian, a policeman in Bloody Men, saw the other side of Chow Yun Fat as a killer. The same is true of the relationship between Jean Reno and Andy Lau in Grand Theft Auto. Jean Reno mentioned why he always wanted to catch Andy Lau, just because "he is the worst thief, he has patience and integrity", and the two gradually got to appreciate each other, and then they cooperated.

It is understandable to join the confrontation between Jean Reno and Andy Lau, which may make the film more interesting. However, Feng Delun made a mistake in controlling the overall rhythm, which made the final presentation more confusing. Moreover, it is an old routine for two people to reach an agreement to fight together, which can be expected from Jean Reno’s constant mention of the reasons for arresting him.

Next Page: Character Settings

Covid-19 is strong in the north and weak in the south？ The later, the lighter the ＂yang＂ symptom？ Zhong Nanshan’s latest interpretation is coming.

　　Zhong Nanshan. The pictures in this article are all live screenshots of the "National University Anti-epidemic Lecture Hall"

　　Is it true that Covid-19 is "strong in the north and weak in the south" recently rumored on the Internet? Is Omicron infected once equivalent to a vaccination? Whether it is early or late, it is better to be together; Or the later you "turn yang", the lighter your symptoms will be? Under what circumstances should I go to the hospital? How do individuals protect themselves?

　　On the afternoon of December 15th, Zhong Nanshan, an academician of China Academy of Engineering, gave a theme sharing on "the dynamics of the epidemic situation in COVID-19 and its countermeasures" at the "National Lecture Hall on Anti-epidemic in Colleges and Universities" hosted by Sun Yat-sen University, Peking University and Tsinghua University, and answered the above questions.

　　Zhong Nanshan believes that there is no essential difference between the two strains. At the same time, he mentioned that one infection with Omicron is equivalent to one vaccination, but he did not agree with the statement that "it is better to be positive early and late, so it is better to be positive together". He said that the later "yang changes", the lighter the symptoms after infection may be. He believes that more and more infected people will be asymptomatic in the end.

　　Covid-19 is "strong in the north and weak in the south"?

　　Recently, some netizens think that after being infected with Omicron mutant, the symptoms of the northern infected people are more serious than those of the southern infected people.

　　Zhong Nanshan also noticed the online related statements. In this regard, he said that at present, Omicron mutant BF.7 is popular in Beijing and Baoding, and Omicron mutant BA.5.2 is popular in Guangzhou and Chongqing. BF.7, the abbreviation of BA.5.21.7, is a mutant strain based on BA.5.2. Generally speaking, there is no obvious difference between the two strains.

　　Zhong Nanshan said, "In fact, there are also some infected people with high fever and obvious body pain in Guangzhou. In Beijing, it seems that the fever is relatively high and the whole body aches, which may be related to the temperature or the further escape of the strain. "

　　In addition, Zhong Nanshan mentioned that there is no more evidence, including the statement that "the virulence of the strains in Chaoyang District of Beijing is strong, and the virulence of the strains in Haidian District of Beijing is weak".

　　Zhong Nanshan believes that there is no essential difference between the two strains.

　　Zhong Nanshan also mentioned that at present, most people have no obvious performance after being infected with Omicron, that is, asymptomatic infected people; Some people have dry throat, sore throat, dry cough, headache, fever and other symptoms, that is, mild patients. Asymptomatic infections and mild patients reached 98%.

　　One infection is equivalent to one vaccination?

　　Regarding the "sequela" of COVID-19, Zhong Nanshan said that there are more than 200 symptoms of "sequela" of COVID-19, the main clinical manifestations of which are cough, dyspnea, olfactory dysfunction, fever, joint and muscle pain, headache, chest pain, brain fog (difficulty in concentration), sleep disorder, fatigue, fatigue and mood change.

　　Zhong Nanshan mentioned that a Scottish study showed that asymptomatic infected people basically have no sequelae. At the same time, patients who have been vaccinated before infection have a lower risk of "sequelae" after infection, such as a 42% decrease in the risk of olfactory disorder, a 39% decrease in the risk of taste disorder, and a 40% decrease in the risk of hearing disorder.

　　Zhong Nanshan also said that at present, many data show that after being infected with Omicron once, the rate of reinfection within one year is very small. After being infected with Omicron once (including asymptomatic), it is actually like being vaccinated once, and antibodies will be produced in the body.

　　In this case, shouldn’t it be as some people on the Internet say, "It’s better to be sunny early and sunny late than to be sunny together"? Zhong Nanshan believes that this concept is not desirable.

　　Zhong Nanshan said that although Omicron (BA.4/5, BF.7) infection is not terrible, most people can fully recover in 7-10 days; However, it is still very important to prevent infection, because China has a large population base, so we should be careful to prevent large-scale infection from affecting the normal social order or leading to the emergence of new mutant strains in the short term.

　　In addition, Zhong Nanshan mentioned that people should not take the initiative to get sick, but because Omicron is highly contagious, there is a high probability of infection. However, the later the infection is delayed, the symptoms after infection may become lighter and lighter. "I believe that in the end, more and more infected people will be asymptomatic." Zhong Nanshan said.

　　How do individuals protect themselves?

　　At present, the spread of Omicron is very strong. How can individuals protect themselves?

　　In this regard, Zhong Nanshan put forward eight suggestions to strengthen personal protection: strengthening protection (wearing masks, keeping a distance, reducing public gathering, etc.); Don’t be afraid of infection; Most infected people don’t need to go to the hospital; Pay attention to antigen testing at home; If you continue to have fever, you must go to the hospital; Older people suffering from general chronic diseases should also be vaccinated; It is not necessary to hoard medicine; "Old drugs are used for new purposes" must undergo rigorous experiments.

　　In view of how young people cope with COVID-19, Zhong Nanshan also mentioned that the serious illness rate of young people infected with COVID-19 is very low. If there are no early warning symptoms in self-health monitoring after infection, they can continue to be isolated at home and release more resources for fever clinics and emergency treatment to elderly patients who need it more.

　　"But if there are suspicious warning symptoms after self-health monitoring, you still need to see a doctor nearby in time." Zhong Nanshan said, "During the peak period of the epidemic, people who live with the elderly should also be vaccinated and strengthened, consciously reduce unnecessary going out and gathering, and do a good job of self-protection when going out to avoid infection. If there are suspected infection symptoms, the antigen self-test should be carried out in time. If it is positive, it should be isolated from itself (single room) to reduce contact with the elderly at home. "

　　Zhong Nanshan has repeatedly stressed that it is necessary to accelerate the intensified vaccination of vaccines (especially heterogeneous vaccines). He pointed out that the effect of preventing infection will not be enhanced if the same vaccine continues to be vaccinated, but the effect of preventing severe diseases still exists; The effect of immunization with heterologous vaccine (subunit protein vaccine/adenovirus vaccine /mRNA vaccine on the basis of two doses of inactivated vaccine) is obviously improved. Therefore, it is necessary to strengthen the immunization of the elderly and vulnerable groups. At the same time, it is necessary to strengthen the vaccine protection of medical personnel, and accelerate the research and development and approval of nasal spray and inhalation vaccines.

Attention! Regarding bank accounts and mobile payments, the central bank’s regulations have changed.

　　CCTV News:Recently, the People’s Bank of China issued the Notice on Improving the Classified Management of Personal Bank Accounts (hereinafter referred to as the Notice), which optimized and improved the opening of accounts, identity authentication and account use, expanded the application scope of Class II and III accounts, and promoted Class II and III households to become the main channels for individuals to handle online payment, mobile payment and other small consumption payment services.

　　The "Notice" issued this time clearly requires that before the end of June 2018, banking financial institutions such as state-owned commercial banks and joint-stock commercial banks should handle personal II and III account opening and other services at the counter of the bank and electronic channels such as online banking, mobile banking, direct banking, remote video teller machines and intelligent teller machines. Before the end of December 2018, other banks should meet the above requirements. By then,Individuals can choose convenient channels among various account opening channels to open Class II and III accounts according to their own usage habits.

　　In December 2015, the central bank initiated the reform of personal bank account system, and divided personal bank accounts into three types of accounts with different authority levels. Among them,Class I accounts are fully functional accounts., that is, the debit card or savings passbook used daily;Class II accounts have the function of "financial management+payment", which can be electronic accounts or bank cards.Class III accounts can only make small consumption and payment, and basically belong to electronic accounts.Figuratively speaking, three types of bank accounts are like three wallets with different funds:

　　Class I households are "cash boxes", and the main sources of funds such as personal wages and incomes are stored in this account;

　　Type II households are "wallets", through which individuals can make daily credit card purchases, online shopping and online payment, and can also purchase investment and wealth management products from banks;

　　Class III households are "coin purses", which are especially suitable for emerging payment methods such as mobile payment.

　　On September 30, 2016, the central bank issued a notice stipulating that from December 1, 2016, everyone can only open one Class I account in each bank. If a Class I account has been opened, a Class II account or a Class III account should be opened.

　　Simplification of account opening procedures for II and III households

　　The "Notice" has optimized account management, which simplifies account opening procedures and clarifies individuals.When opening Class II and III accounts by using secure and reliable authentication methods such as digital certificates or electronic signatures, if I am bound to my Class I account or credit card account, and my personal identity data or information has not changed, I don’t need to fill in my identity information or show my identity documents when opening Class II and III accounts.Prior to this, the opening of Class II and III accounts required verification of personal identity information.

　　While providing convenience for opening an account, the document does not relax the customer identification requirements. For opening a Class III account, the Notice stipulates that,An account that has been verified by real-name registration system must be bound.When the total amount of bilateral receipts and payments of the same person’s funds in all Class III households in a bank reaches more than 50,000 yuan (inclusive), the individual shall be required to provide valid identity documents within 7 days, and keep copies, photocopies or images of the identity documents, and register other basic identity information such as personal occupation, domicile or work unit address, and validity period of the documents.

　　△ Figure/vision china

　　Optimization and improvement of the noticeClass II and III accounts

　　In terms of opening Class II and III accounts,

　　Since the date of issuance of the Notice, the same bank legal person is the same person.In principle, the number of Class II and III households opened shall not exceed 5 respectively.. In the direction of use, "actively guide individuals to use Class II and III households instead of Class I households for online payment and mobile payment services,Use Class II and III households to handle daily consumption, pay public utility fees, and recharge payment accounts.. "

　　 △ Figure/vision china

　　In terms of class III household quota,

　　The "Notice" requires the key promotion and application of Class III households. On the premise of meeting the requirements of anti-money laundering and anti-fraud, relax the restrictions on the use of Class III households.The upper limit of the balance of Class III household accounts has been raised from 1000 yuan to 2,000 yuan.To better meet the daily micro-payment needs of the public.

　　Ii, iii households cash withdrawal.

　　"Notice" stipulates that Class II and III households can use technologies based on host card simulation (HCE), mobile phone security unit (SE) and payment Tokenization.Mobile payment tools for small cash withdrawals.The amount of cash withdrawal shall be set by the bank according to the risk level and transaction situation of customers under the premise of complying with the provisions of the total withdrawal limit of Class II and III households.

　　Class ⅲ householdsIn terms of granting loans

　　Previously, the authority of Class III accounts without loan function was released. According to the new regulations,The bank may issue the bank’s small consumption loan funds to Class III households and repay them through Class III households, but Class III households may not overdraw directly.. Prior to this, only Class I and II households had this right.

　　△ Figure/vision china

　　▌ This article Source: CCTV News, Beijing Daily

Russian Interview Notes 6： Ubiquitous Polarization

Thematic reading guide:To commemorate the 60th anniversary of the establishment of diplomatic relations between China and China, CCTV News Channel broadcast a large-scale news feature film "Focus on Russia" from June 15th to 26th, with a total of 10 episodes, selecting the focus issues that interest Russians or are related to Russians, involving economic, education, commerce, science and technology, sociology and other fields, and introducing all aspects of contemporary Russian society to China audiences. Through the program Focus on Russia, the audience in China will see a complete sense of Russia.

Roewe’s ＂trump card＂ has come, with rich configuration.

Everyone must think about their actual needs when buying a car, so as to have a more targeted choice. Today, Xiaobian picked a car and introduced it to everyone. It is. Let’s take a look at it together.

Let’s take a look at the appearance of Roewe i5 first. The design of Roewe i5 front is relatively simple, and it looks very personalized with multi-banner grille. Then the clean and refreshing headlight design is adopted, and the visual effect coincides with the positioning of the whole vehicle. The car is equipped with LED daytime running lights, delayed shutdown and so on. Coming to the side of the car, the size of the car body is 4676 mm * 1838 mm * 1498 mm. The car adopts fashionable and simple lines, giving people a very simple feeling. With large-sized thick-walled tires, it looks full of movement. In the rear part, the Roewe i5 rear line is dynamic and lively, and the taillights give people a very domineering and stylish feeling. Together with the unique exhaust pipe, the overall look is very angular.

Sitting in the car, Roewe i5 interior enhances the sense of visual exquisiteness, and the overall recognition is very high. The steering wheel of the car is very elegant in shape, equipped with functions such as manual adjustment of the steering wheel up and down, and the visual effect is good. Let’s take a look at the central control. The design of the center console is reasonable, which makes the interior style impressive and looks unique. Let’s take a look at the dashboard and seats again. The dashboard of this car presents a fashionable and sporty design style and looks strong in science and technology. The car uses leather seats, which are spacious and thick, with exquisite materials and comfortable ride.

Roewe i5 is matched with continuously variable transmission (CVT) gearbox, with maximum power of 95KW and maximum torque of 158N.m.

The car is equipped with traction control (ASR/TCS, etc.), Bluetooth /WIFI connection, cruise control, voice control, intelligent key and other configurations, and the configuration has reached the mainstream level of the same level.

The moderate size of the car is a very suitable choice for many families, and the internal space is enough for daily use in families. If you just need such a travel tool, you may wish to experience it quickly.

Recall Lexus in China

Wanche. com expert Zeng Jian

Engaged in automobile maintenance for many years, with rich theoretical knowledge and practical maintenance experience. He also has a deep understanding of vehicle insurance, loss claims and vehicle service procedures.

    

case

Recently, Toyota Motor (China) Investment Co., Ltd. submitted a recall report to the General Administration of Quality Supervision, Inspection and Quarantine, and recalled some imported Lexus)LS series vehicles from July 19, 2010. According to statistics, there are 5,791 vehicles involved in Chinese mainland.

The reason for the defect is that the strength of the spring is reduced due to the tiny foreign matter mixed in the material of the intake and exhaust valves of the engine, which may cause damage. In this case, the engine will produce abnormal noise and cause poor work. In the worst case, the engine may stop working while driving, which is a potential safety hazard.

    

Expert diagnosis

The function of the valve spring mainly includes the following aspects: (1) to ensure that the intake and exhaust valves automatically return to close and seal; (2) Ensure the seating pressure between the valve and the valve seat; (3) Absorb the inertia force generated by the transmission parts during the opening and closing of the valve, so as to prevent various transmission parts from separating from each other and damage the normal operation of the valve train.

The fatigue life of valve spring mainly depends on working stress, material strength, surface quality, internal quality and manufacturing quality. Automobile valve spring belongs to cylindrical compression coil spring. Under the action of axial force, the shear stress on any cross section of the spring is the largest in the inner diameter of the spring and the smallest in the outer diameter. Therefore, the source of fracture failure and crack caused by design and material strength is often inside the spring.

Because the valve spring has been under the action of alternating stress, if there is a quality problem, the valve spring will have abnormal sound at first, and the acceleration performance of the car will decrease in serious cases, accompanied by difficulties in starting and poor working of individual cylinders.

When the valve spring breaks, the noise of the engine will increase, and in serious cases, the valve will not fully return, which will cause the piston to collide with the intake and exhaust valves, bend the valve stem, damage the piston, and even cause the cylinder head or cylinder block to be scrapped. At the same time, the engine will suddenly shut down, which will easily lead to serious traffic accidents.

    

Expert reminder

How to diagnose valve spring fracture? Whether the valve spring is broken can be seen by disassembling the valve chamber cover. When the engine speed changes, the valve spring will make obvious irregular noise; In static state, you can pry the spring with tools to check it, or you can slide the spring with tools. If the sound is different from other springs and hoarse, it means that the spring is cracked or broken and should be replaced in time.

What should I do when I find that the valve spring is broken? If several springs break at the same time on the way, which has affected the normal running of the vehicle, the driver must stop the engine in time. If there are no accessories or you can’t contact the 4S shop for the time being, you can find a professional maintenance person to remove the broken spring, face the flat parts at both ends, and then install it on the valve stem in the original way. This can temporarily ensure the normal operation of the engine, but the valve spring must be replaced in time after arriving at the 4S shop or the place where the 4S shop can be contacted.

 

  Tips

valve spring

The valve spring is a cylindrical spiral spring and belongs to the valve train of the engine. The function of the valve train is to open and close the intake and exhaust valves regularly according to the needs of the working process of each cylinder of the engine, so that the fresh combustible mixture can enter the cylinder in time and the exhaust gas can be discharged from the cylinder in time.

 

Qichen big V DD-i super hybrid king returns! Starting from 169,900

As a compact suv, Qichen V DD-i Super Hybrid has many highlights. Let’s take you to appreciate its style.

First of all, from the appearance, the style of Qichen V DD-i super hybrid front looks very stylish and stylish, and looks more spiritual. Coupled with comfortable headlights, you can see many interesting details from the inside. The car is equipped with LED daytime running lights, automatic opening and closing, delayed closing and so on. Coming to the side of the car body, the size of the car body is 4607 mm * 1917 mm * 1624 mm. The car adopts simple and elegant lines, and the side circumference looks very calm. With large-sized thick-walled tires, the shape is quite deep. In the rear part, the rear of the car echoes the front face from a distance, and the taillights are very beautiful, and the whole looks very calm.

Sitting in the car, Qichen V DD-i super hybrid interior is angular, giving people a very simple and fashionable feeling. The steering wheel design of this car is very simple and fashionable, equipped with the functions of manual steering wheel up and down+front and rear adjustment, and its shape is unique. Let’s take a look at the central control. The design of the center console is reasonable, which makes the interior style impressive. The overall design of the central control is very good. The dashboard and seats give people a good feeling, too. Let’s take a look. The dashboard of this car presents an elegant design style and looks very simple. The car adopts leather seats, which are wide and thick, further improving the comfort of drivers and passengers.

The space performance of Qichen V DD-i super hybrid trunk is quite satisfactory. If some large objects need to be installed, the rear seats also support proportional tilting, which is enough for home use. In addition, the car is equipped with fatigue warning, anti-lock braking (ABS), LED daytime running lights, brake assist (EBA/BAS, etc.), brake force distribution (EBD) main driver airbag, co-pilot airbag and front side airbag.

I wonder if you are excited about this car introduced today? If you are interested, you might as well take a test drive, which will definitely bring you a different feeling.

Price reduction information of BMW i4 in Xi ‘an, with a discount of 90,000! Limited time special offer

[car home Xi ‘an Preferential Promotion Channel] Recently, we learned that there is a large preferential activity in Xi ‘an, and the maximum preferential amount can reach 90,000 yuan. After this price reduction, the minimum starting price of BMW i4 has dropped to 339,900 yuan. If you are interested in buying this model, you might as well hurry up and click "Check the car price" in the quotation form to get a higher discount.

西安地区宝马i4降价信息，优惠9万！限时特惠

The exterior design of the BMW i4 is unique. The front face of the BMW i4 adopts a family-owned kidney-shaped air intake grille, but it is different from the traditional fuel vehicle. It adopts a closed design, which symbolizes the future of electrification. The body lines are smooth, showing a sense of movement and technology. The rear part is simple and generous, and the taillights are unique in shape, which echoes the front face design. The overall style shows the consistent luxury and sports characteristics of the BMW brand.

西安地区宝马i4降价信息，优惠9万！限时特惠

BMW i4 is famous for its streamlined body design and dynamic lines, with the length, width and height of 4,785 * 1,852 * 1,455 mm and the wheelbase of 2,856 mm, providing spacious and comfortable interior space. The front and rear wheel tracks are 1601 mm and 1630 mm respectively, which further improves the stability and handling of the vehicle. With 18-inch rims, the front tyre size is 245/45 R18 and the rear tyre size is 255/45 R18, which not only enhances the vehicle’s grip, but also endows it with a unique sports style.

西安地区宝马i4降价信息，优惠9万！限时特惠

The interior design of BMW i4 inherits BMW’s consistent luxury and technological style, which is simple and modern. The steering wheel is made of genuine leather, which has excellent hand feeling and supports manual adjustment up and down and back and forth to meet the usage habits of different drivers. The center console is equipped with a 14.9-inch touch screen and advanced multimedia system, navigation and voice recognition control system, which makes the operation more convenient and intelligent. In addition, there are USB and Type-C interfaces under the center console, which is convenient for users to charge mobile devices. There are many choices of seat materials, including imitation leather, genuine leather and leather /Alcantara mix, which provides a comfortable riding experience. The main and co-pilot seats are equipped with a variety of adjustment methods, including front and rear, backrest, height, leg rest and lumbar support adjustment, to ensure the comfort of drivers and passengers. The front seats also have a heating function to increase the comfort of driving in winter. In addition, the driver’s seat is also equipped with electric seat memory function, which is convenient for personalized setting. The rear seats can be laid down in proportion to provide more luggage space.

西安地区宝马i4降价信息，优惠9万！限时特惠

BMW i4 is equipped with an efficient engine with a maximum power of 210 kW and a maximum torque of 400 Nm, providing excellent power output and driving experience for the vehicle.

The owner of car home spoke highly of the BMW i4, and he specifically mentioned that the vehicle has good sound insulation effect, abundant power and the design is king-class, while the volcanic red interior made him feel that he would not lose Mercedes.